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Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 287-291 doi: 10.1007/s11684-009-0050-5

Abstract: In order to explore the role of cyclin-dependent kinase 4 (cdk4) in neurodegenerative diseases, lentiviral-deliveredRNA interference (RNAi) was used to silence the expression of the murine cdk4 gene .Three cdk4-shRNAs of mouse and a negative sequence were designed.The cdk4-siRNA2 was the most effective in silencing cdk4.Lentivector-mediated RNAi could efficiently down-regulate the expression of the murine cdk4 gene , which

Keywords： cyclin-dependent kinase 4     RNA interference     plasmid     lentiviral vector    

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Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma

Frontiers of Medicine doi: 10.1007/s11684-023-0999-5

Abstract: EMT, and stemness maintenance by increasing the expression of FAT1 and facilitating the FAT1-mediated CDK4, our work suggests that GTF2I transferred by MSC-EVs confer antioncogenic effects through the FAT1/CDK4

Keywords： thyroid carcinoma     mesenchymal stem cell     extracellular vesicle     GTF2I     FAT1     CDK4    

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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 290-303 doi: 10.1007/s11684-022-0956-8

Abstract: In terms of mechanism, CDK2 was identified as a target of benzydamine by molecular docking, pull-downSpecifically, benzydamine inhibited the growth of ESCC cells by inhibiting CDK2 activity and affectingOur study illustrates that benzydamine inhibits the growth of ESCC cells by downregulating the CDK2 pathway

Keywords： benzydamine     cyclin-dependent kinase 2     patient-derived xenograft     esophageal squamous cell carcinoma    

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Discovery of small molecule degraders for modulating cell cycle

Frontiers of Medicine   Pages 823-854 doi: 10.1007/s11684-023-1027-5

Abstract: The selectivity, application, validation and the current state of each CDK degrader will be overviewedAdditionally, possible methods are discussed for the development of degraders for CDK members that stillOverall, this article provides a comprehensive summary of the latest advancements in CDK and cyclin protein

Keywords： PROTAC     molecular glue     degrader     cell cycle     CDK     cyclin    

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The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 384-389 doi: 10.1007/s11684-009-0070-1

Abstract: In the present report, cyclin-dependent kinase1 (CDK1) siRNA was transfected into cells to silence theCDK1 gene expression and study its role in the cell cycle and cell apoptosis.The siRNA targeting CDK1 gene was chemically synthesized and transfected into Hela cells by lipofectamineThe expression levels of CDK1 gene and protein were examined by real-time quantitative polymerase chainCDK1 gene was successfully silenced by its siRNA, and the CDK1 protein expression level was decreased

Keywords： cyclin-dependent kinase1     siRNA interference     cell cycle     apoptosis    

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ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11,   Pages 1728-1740 doi: 10.1007/s11705-023-2322-z

Abstract: A novel Z-scheme ZnFe2O4/BiVO4 heterojunction photocatalyst was successfullyCompared with the single-phase counterparts, ZnFe2O4/BiVO4 demonstratedConsequently, the 30% ZnFe2O4/BiVO4 catalyst afforded a degradationorganic carbon removal rate of 50%, which is an excellent activity compared with ever reported BiVO42O4/BiVO4 heterojunctions were quite

Keywords： ZnFe2O4/BiVO4     Z-scheme heterojunction     photocatalytic degradation    

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Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 374-382 doi: 10.1007/s11708-017-0494-2

Abstract: The preparation of Li SiO -coated LiNi Mn O materials by sintering the SiO -coated nickel-manganese oxides with lithium salts using abundant and low-cost sodium silicate as the silicon source was reported. The samples were characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. It was found that a uniform and complete SiO coating layer could be obtained at a suitable pH value of 10, which transformed to a good Li SiO coating layer afterwards. When used as the cathode materials for lithium-ion batteries, the Li SiO -coated LiNi Mn O samples deliver a better electrochemical performance in terms of the discharge capacity, rate capability, and cycling stability than that of the pristine material. It can still deliver 111.1 mAh/g at 20 C after 300 cycles, with a retention ratio of 93.1% of the stable capacity, which is far beyond that of the pristine material (101.3 mAh/g, 85.6%).

Keywords： lithium-ion batteries     cathode material     LiNi0.5Mn1.5O4     lithium-ion conductor    

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Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1224-2

Abstract: zero-valent zinc coupled with ascorbic acid (ZVZ/AA) was developed and applied to debrominate the 2,2′,4,4ZVZ particles and 3 mmol/L AA at original solution pH= 4.00 using the solvent of methanol/H2O (v:v= 4:

Keywords： 2     2′     4     4′-tetrabromodiphenyl ether (BDE-47)     Ascorbic acid     Reductive debromination     Zero-valent zinc    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: In the present study, replication factor c subunit 4 (RFC4) is a key potential target involved in NPCFurthermore, the expression and mechanism of RFC4 in NPC were investigated in vitro and inOur results revealed that RFC4 was more elevated in NPC tumor tissues than in normal tissues.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro andInterestingly, HOXA10 was confirmed as a downstream target of RFC4, and the overexpression of HOXA10

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Laws of 4D Printing Article

Farhang Momeni, Jun Ni

Engineering 2020, Volume 6, Issue 9,   Pages 1035-1055 doi: 10.1016/j.eng.2020.01.015

Abstract: Accordingly, four-dimensional (4D) printing is a manufacturing process that involves multiple researchfields. 4D printing conserves the general attributes of 3D printing (such as material waste reductionThe main difference between 3D- and 4D-printed structures is the presence of one additional dimensionshow that two types of time constants are needed to capture the correct time-dependent behavior of 4Dintroduce the concept of mismatch-driven stress at the interface of active and passive materials in 4D

Keywords： Manufacturing     Stimuli-responsive materials     Mechanics of materials     Time constant     4D printing    

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Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1090-1100 doi: 10.1007/s11705-021-2091-5

Abstract: Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesized

Keywords： synthesis     pyrimidin-4-amine derivatives     1     2     4-oxadiazole     insecticidal activity     structure-activity    

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Identifying stakeholders’ roles and relevant project documents for 4D-based collaborative decision making

Veronika BOLSHAKOVA, Annie GUERRIERO, Gilles HALIN

Frontiers of Engineering Management 2020, Volume 7, Issue 1,   Pages 104-118 doi: 10.1007/s42524-019-0041-4

Abstract: To fully understand and effectively implement 4D building information modelling (BIM) models and methodsThis article studies the convergence between uses of 4D BIM and digital project documents.We hypothesize that a clear visualization of the construction simulation through a 4D model is a usefulIt then introduces a proposition for 4D BIM uses implementation by the project development phase.It concludes by summarizing stakeholders’ roles and documents relevant to 4D BIM uses.

Keywords： BIM     4D BIM     4D BIM use     AEC project management     collaboration     decision making    

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Review of 4Pi Fluorescence Nanoscopy Review

Xiang Hao, Yiming Li, Shuang Fu, Yanghui Li, Yingke Xu, Cuifang Kuang, Xu Liu

Engineering 2022, Volume 11, Issue 4,   Pages 146-153 doi: 10.1016/j.eng.2020.07.028

Abstract: An important milestone in this pursuit is the coherent utilization of two opposing objectives (4Pi geometryHerein, we review the recent progress in 4Pi nanoscopy, which provides a 3D, non-invasive, diffraction-unlimitedThis review includes both the targeted and stochastic switching modalities of 4Pi nanoscopy.The schematics, principles, applications, and future potential of 4Pi nanoscopy are discussed in detail

Keywords： Fluorescence nanoscopy     Super-resolution imaging     4Pi nanoscopy     IsoSTED     4Pi-SMLM    

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Preliminary Investigation of the Reversible 4D Printing of a Dual-Layer Component Article

Amelia Yilin Lee, Jia An, Chee Kai Chu, Yi Zhang

Engineering 2019, Volume 5, Issue 6,   Pages 1159-1170 doi: 10.1016/j.eng.2019.09.007

Abstract: manufacturing and advances in shape memory materials have fueled the progress of four-dimensional (4DWith increasing improvements in design, reversible 4D printing—or two-way 4D printing—hasneed for human interference, as the programming is completely driven by external stimuli, which allows 4D-printedThis study proposes a new reversible 4D printing actuation method.This understanding of the curvature will provide a great degree of control over the reversible 4D-printed

Keywords： 4D printing     Additive manufacturing     Shape memory polymer     Reversible 4D printing     Two-way 4D printing    

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Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Frontiers of Chemical Science and Engineering 2008, Volume 2, Issue 2,   Pages 220-223 doi: 10.1007/s11705-008-0041-0

Abstract: L-4-Fluorophenylalanine (FPhe) was prepared from 4-fluorophenylpyruvate (FPPA) catalyzed by aspartate

Keywords： L-4-Fluorophenylalanine     Asp-AT     aspartate aminotransferase     4-fluorophenylpyruvate     FPPA    

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Title Author Date Type Operation

Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene

Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,

Journal Article

Extracellular vesicle-carried GTF2I from mesenchymal stem cells promotes the expression of tumor-suppressive FAT1 and inhibits stemness maintenance in thyroid carcinoma

Journal Article

Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma

Journal Article

Discovery of small molecule degraders for modulating cell cycle

Journal Article

The role of CDK1 siRNA interference in cell cycle and cell apoptosis

Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,

Journal Article

ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic

Journal Article

Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

Journal Article

Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Laws of 4D Printing

Farhang Momeni, Jun Ni

Journal Article

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Journal Article

Identifying stakeholders’ roles and relevant project documents for 4D-based collaborative decision making

Veronika BOLSHAKOVA, Annie GUERRIERO, Gilles HALIN

Journal Article

Review of 4Pi Fluorescence Nanoscopy

Xiang Hao, Yiming Li, Shuang Fu, Yanghui Li, Yingke Xu, Cuifang Kuang, Xu Liu

Journal Article

Preliminary Investigation of the Reversible 4D Printing of a Dual-Layer Component

Amelia Yilin Lee, Jia An, Chee Kai Chu, Yi Zhang

Journal Article

Recombinant aspartate aminotransferase-catalyzed synthesis of L-4-fluorophenylalanine

CHEN Meijuan, JIA Honghua, CHEN Yongsheng, JIANG Min, WEI Ping

Journal Article